11 Mai 023 - Sérafin GUTIEREZ unité ASTRE du Cirad

Towards a model of virome assembly in mosquitoes based on host taxonomy

Mosquitoes harbour a large diversity of eukaryotic viruses beyond the well-known viral pathogens of humans. Those virus communities or viromes can influence mosquito physiology as well as the transmission of human pathogens. Nevertheless, we lack robust data on potential deterministic patterns in virome assembly. Identifying such patterns (or their absence) is an essential step towards tests of virome influence on mosquito physiology and pathogen transmission to vertebrates. During my talk, I will present data from our group on the assembly patterns in the mosquito virome. Based on our results and those of others, we propose a new model of virome assembly in mosquitoes based on host taxonomy. In this model, differences in relative abundance of shared viruses would dominate between the viromes of closely-related hosts (i.e. between populations of a mosquito species, or between closely-related mosquito species). The dominant difference would change along with host taxonomic distance. Thus, differences in virus diversity would prevail between unrelated mosquito species. This preliminary model has yet limited empirical support and requires more studies exploring its validity.

Publiée : 02/05/2023